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Fluconazole is a prescription azole antifungal medication that may be used to treat serious fungal or yeast infections affecting the vagina, mouth or throat, lungs, bladder, or blood. It is available as an oral tablet, suspension, or injectable form. Examples of conditions treated by fluconazole include vaginal candidiasis, oropharyngeal candidiasis, esophageal candidiasis, and cryptococcal meningitis.